Elevated atherogenic index of plasma in multiple sclerosis: association with metabolic profile in a cross-sectional study.

In a study with 200 participants (100 with relapsing-remitting MS and 100 controls), levels of total cholesterol, LDL cholesterol, triglycerides, and atherogenic index of plasma (AIP) were significantly higher in MS patients. AIP was independently associated with MS presence, but no link was found with disease severity or treatment effects.

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Source: Read original source (PMID 42855663)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Why it matters

These findings suggest a connection between metabolic dysregulation and MS, potentially highlighting systemic inflammatory components related to the disease.

What this does not prove

As an observational cross-sectional study, it cannot establish causation, and results may not apply to all MS subtypes or populations.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Observational
Participants / samples: 200 · basis not reported
Randomised: No
Controlled: Yes
Primary endpoint met: Yes
Relevant MS type: RRMS
Publication date: 2026-08-06
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Other

Original sources

Primary evidenceElevated atherogenic index of plasma in multiple sclerosis: association with metabolic profile in a cross-sectional study. ↗DOI: 10.1186/s12883-026-05230-8

Supporting passages (12)

study designIn this retrospective cross-sectional study, 100 patients with relapsing-remitting MS (RRMS) and 100 age- and sex-matched healthy controls were included.

subjects100 patients with relapsing-remitting MS (RRMS) and 100 age- and sex-matched healthy controls were included.

sample size100 patients with relapsing-remitting MS (RRMS) and 100 age- and sex-matched healthy controls were included.

randomizedMETHODS: In this retrospective cross-sectional study, 100 patients with relapsing-remitting MS (RRMS) and 100 age- and sex-matched healthy controls were included.

controlledIn this retrospective cross-sectional study, 100 patients with relapsing-remitting MS (RRMS) and 100 age- and sex-matched healthy controls were included.

peer reviewedBMC neurology

primary endpoint metAIP values were significantly elevated in the MS group (0.45 ± 0.26 vs. 0.37 ± 0.23; p = 0.020).

research categoriesElevated AIP and an atherogenic lipid profile in patients with MS support the presence of systemic metabolic and inflammatory components in the disease.

relevant ms types100 patients with relapsing-remitting MS (RRMS) and 100 age- and sex-matched healthy controls were included.

publication date2026-08-06

findingsRESULTS: Total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and AIP levels were significantly higher in patients with MS compared to controls (all p < 0.05), whereas no significant difference was observed in HDL levels.

limitationsTitle: Elevated atherogenic index of plasma in multiple sclerosis: association with metabolic profile in a cross-sectional study.

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