Human Participants with Multiple Sclerosis: Rehabilitation Study

In a study of 122 people with multiple sclerosis, combining multidisciplinary rehabilitation (MDR) with 12 sessions of excitatory rTMS led to clinically meaningful gait improvements in 24.6% (Timed 25-Foot Walk Test) and 48.4% (6-Minute Walk Test) of participants. Furthermore, changes in resting motor threshold (RMT) slope were linked to improvements in the T25FW test.

Tags: #Rehabilitation
Most relevant to: —
Source: Read original source (PMID 42850194)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Why it matters

These findings suggest that both MDR and rTMS can positively influence gait in people with MS. The relationship between RMT and gait improvement may help tailor rehabilitation strategies.

What this does not prove

The study is observational and retrospective, meaning the results do not establish causation. Additionally, no association was found between RMT and 6MWT improvement.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Observational
Participants / samples: 122 · Number of pwMS undergoing inpatient MDR combined with rTMS
Randomised: No
Controlled: Not reported
Primary endpoint met: Yes
Relevant MS type: All
Publication date: 2026-10-05
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Rehabilitation, Other

Original sources

Primary evidenceResting motor threshold as a predictor of rehabilitation outcomes in multiple sclerosis. ↗DOI: 10.1016/j.clinph.2026.2112434

Supporting passages (14)

study designWe retrospectively analysed 122 pwMS undergoing inpatient MDR combined with 12 sessions of excitatory rTMS.

subjectsOBJECTIVE: To investigate resting motor threshold (RMT) as a predictor of clinically meaningful gait improvement after multidisciplinary rehabilitation (MDR) + rTMS in people with Multiple Sclerosis (pwMS).

sample sizeWe retrospectively analysed 122 pwMS undergoing inpatient MDR combined with 12 sessions of excitatory rTMS.

sample size basisMETHODS: We retrospectively analysed 122 pwMS undergoing inpatient MDR combined with 12 sessions of excitatory rTMS.

randomizedNo

peer reviewedClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

primary endpoint metRMT slope significantly predicted improvement at the T25FW, even after accounting for baseline motor performance, baseline RMT, and clinical and sociodemographic covariates.

research categoriesRMT slope may be a feasible rule-out biomarker to identify likely non-responders and support precision rehabilitation strategies.

relevant ms typespwMS.

publication date2026-10-05

interventionMDR combined with 12 sessions of excitatory rTMS.

primary endpointGait was assessed pre- and post-treatment using the Timed 25-Foot Walk Test (T25FW) and the 6-Minute Walk Test (6MWT).

findingsClinically meaningful improvement occurred in 24.6 % (T25FW) and 48.4 % (6MWT) of pwMS.

limitationsTitle: Resting motor threshold as a predictor of rehabilitation outcomes in multiple sclerosis.

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