Human Retrospective Series on ZAP-X Gyroscopic Radiosurgery for Trigeminal Neuralgia
In a study of 50 patients undergoing ZAP-X gyroscopic radiosurgery, 87.5% achieved satisfactory pain control after 12 months, with significant improvement in pain scores (BNI). Treatment-related toxicity occurred in 8.9% of cases, and 26.8% required repeat radiosurgery. Baseline BNI grade V was identified as a significant predictor of treatment failure, while patient demographics did not reliably predict outcomes.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
This study highlights the potential of ZAP-X radiosurgery for effective pain control in trigeminal neuralgia, with a notable success rate and defined metrics for treatment response.
What this does not prove
The study is retrospective, which limits the ability to draw definitive conclusions and indicates a need for further prospective research to validate these findings.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- 50 · retrospective series of patients
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-30
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceGyroscopic Radiosurgery for Trigeminal Neuralgia: Results of a Retrospective Series of >50 Patients. ↗DOI: 10.3390/brainsci16101061
Supporting passages (9)
sample size50
sample size basisTitle: Gyroscopic Radiosurgery for Trigeminal Neuralgia: Results of a Retrospective Series of >50 Patients.
publication date2026-09-30
interventionZAP-X gyroscopic radiosurgery
primary endpointPain outcome was assessed using the Barrow Neurological Institute Pain Intensity Scale (BNI), and sensory toxicity was evaluated using the BNI Facial Numbness Scale.
findingsRESULTS: Following radiosurgery, 87.5% of patients achieved satisfactory pain control (BNI I-IIIb; 95% CI, 78.8-96.2%), with a significant overall improvement in BNI score compared with baseline (p < 0.001) at the 12 months of follow-up. Half of the patients experienced clinical improvement within the first 15 days. Treatment-related toxicity occurred in 8.9% of patients, while 26.8% required repeat radiosurgery during follow-up. The decision to perform retreatment is made when the patient has shown no improvement in the BNI score at 6 months after the initial treatment. Baseline BNI grade V was the only statistically significant predictor of treatment failure, conferring a more than ninefold higher odds of non-response compared with BNI grade IV (OR 9.33; 95% CI, 1.66-52.3; p = 0.011). Female sex showed a nonsignificant trend toward a lower risk of failure (OR 0.65; 95% CI, 0.13-3.24; p = 0.596). Neither multiple sclerosis-associated TN nor other etiological or dosimetric variables significantly predicted treatment failure. A greater number of beams showed a trend toward an increased probability of retreatment (OR 1.01; p = 0.091), although statistical significance was not reached.
limitationsTitle: Gyroscopic Radiosurgery for Trigeminal Neuralgia: Results of a Retrospective Series of >50 Patients.
peer reviewedPublication types: Journal Article
subjectsTitle: Gyroscopic Radiosurgery for Trigeminal Neuralgia: Results of a Retrospective Series of >50 Patients.
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