Systematic Review of Pain-Related Alterations in Models of Multiple Sclerosis and Other Neurological Diseases
A systematic review evaluated 26 studies focusing on pain-related changes linked to inflammatory and neuroimmune pathways in multiple sclerosis and other neurological disease models. The findings highlighted that these alterations are model-dependent, particularly influenced by the type of neurological condition examined.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
Understanding how pain responses are mediated in various neurological conditions can advance research on pain management. It underscores the need for tailored approaches based on specific disease models, which is crucial for developing effective interventions.
What this does not prove
Key limitations include the predominance of studies on experimental autoimmune encephalomyelitis, lack of consistent reporting standards, and potential biases due to sex and age imbalances, affecting the generalizability of the findings across different diseases.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- 26 · Twenty-six studies met the eligibility criteria: sixteen examined multiple sclerosis/experimental autoimmune encephalomyelitis (61.5%), seven Parkinson's disease (26.9%), two Alzheimer's disease-related models (7.7%), and one Huntington's disease model (3.8%); no eligible amyotrophic lateral sclerosis study was identified.
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-10
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceGlial Contributions to Pain in Neurodegenerative Disease Models: A Systematic Review of Microglial and Astrocytic Evidence. ↗DOI: 10.3390/brainsci16101093
Supporting passages (7)
study designSystematic Review
sample size26
sample size basisTwenty-six studies met the eligibility criteria: sixteen examined multiple sclerosis/experimental autoimmune encephalomyelitis (61.5%), seven Parkinson's disease (26.9%), two Alzheimer's disease-related models (7.7%), and one Huntington's disease model (3.8%); no eligible amyotrophic lateral sclerosis study was identified.
publication date2026-10-10
findingsPain-related alterations involved inflammatory, neuroimmune, synaptic, and astrocyte-associated pathways, but the evidence was strongly model-dependent.
limitationsConclusions: The available evidence supports context-dependent associations between glial responses and nociceptive processing; however, marker specificity, EAE predominance, sex and age imbalance, and incomplete reporting of bias control procedures limit causal and cross-disease generalization.
peer reviewedPublication types: Journal Article; Review
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.