Association Between Subjective Sleep Quality and Relapse Status in Relapsing-Remitting MS Patients
In a study with 132 patients having relapsing-remitting MS, it was found that those in relapse were more likely to be classified as poor sleepers (59.1%) compared to those in remission (36.4%). Additionally, higher scores on the Pittsburgh Sleep Quality Index were linked with higher odds of being in relapse (OR = 1.16).
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
These findings suggest a relationship between poor sleep quality and relapse status, indicating potential clinical significance in monitoring sleep for these patients.
What this does not prove
The study does not prove that poor sleep causes relapses and focuses solely on relapsing-remitting MS, which may limit the application of results to other forms of MS.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- 132 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- patients with relapsing-remitting MS
- Size of effect
- OR = 1.16; 95% CI 1.02-1.32
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceSubjective Sleep Quality in Relation to Relapse Status in Relapsing-Remitting Multiple Sclerosis: A Propensity Score-Matched Nested Case-Control Analysis. ↗DOI: 10.3390/neurolint18100198
Supporting passages (10)
sample size132
publication date2026-10-21
comparatorpatients in remission
primary endpointConclusions: Poorer subjective sleep quality was independently associated with relapse status in relapsing-remitting MS, supporting sleep disturbance as a relapse-associated clinical feature rather than a proven causal risk factor.
findingsPatients in relapse were more frequently classified as poor sleepers than those in remission (59.1% vs. 36.4%; p = 0.009).
findingsIn the double-adjusted logistic regression model, higher Pittsburgh Sleep Quality Index scores were independently associated with relapse status (OR = 1.16; 95% CI 1.02-1.32; p = 0.023), whereas the remaining variables were not independently associated with relapse status.
populationpatients with relapsing-remitting MS
effect sizeOR = 1.16; 95% CI 1.02-1.32
limitationsTitle: Subjective Sleep Quality in Relation to Relapse Status in Relapsing-Remitting Multiple Sclerosis: A Propensity Score-Matched Nested Case-Control Analysis.
peer reviewedPublication types: Journal Article
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