Neural Network Differences in Patients with Multiple Sclerosis and Healthy Individuals
The study found that during task switching, healthy controls showed distinct neural network architectures compared to patients with multiple sclerosis (MS). MS patients utilized more local processing strategies, while healthy individuals exhibited enhanced long-range connectivity. Better accuracy in MS patients correlated with stronger self-connectivity modulations.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
These findings underscore the neural differences in processing strategies between MS patients and healthy individuals, providing insights into the cognitive challenges faced by those with MS.
What this does not prove
The study lacks clear primary endpoints or treatment efficacy outcomes.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- No
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-19
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- 57 patients with multiple sclerosis and 57 healthy individuals.
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceAltered network organization with shift to local processing during adaptive behaviour in multiple sclerosis. ↗DOI: 10.1093/braincomms/fcag397
Supporting passages (8)
randomizedNo
sample size basis57 healthy individuals and 57 patients with multiple sclerosis
publication date2026-10-19
findingsSource reconstruction and connectivity analyses revealed distinct neural network architectures and communication strategies during task switching in healthy controls compared to patients with multiple sclerosis.
populationIn the current study, we examined directed neural information transfer in 57 healthy individuals and 57 patients with multiple sclerosis with a focus on brain-behaviour associations during task switching.
limitationsTitle: Altered network organization with shift to local processing during adaptive behaviour in multiple sclerosis.
peer reviewedPublication types: Journal Article
subjectsIn the current study, we examined directed neural information transfer in 57 healthy individuals and 57 patients with multiple sclerosis with a focus on brain-behaviour associations during task switching.
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