Cognitive Phenotypes in Multiple Sclerosis: Observational Study of Human Subjects
An observational study identified four cognitive phenotypes among 369 individuals with multiple sclerosis (MS): preserved cognition, mild verbal fluency involvement, mild attention involvement, and severe multidomain involvement. Differences in brain imaging showed reduced brain volumes in certain groups compared to healthy controls, with more severe cognitive impairment associated with greater brain atrophy and altered functional connectivity.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding these cognitive phenotypes is crucial as cognitive impairment affects a significant proportion of MS patients. Identifying specific phenotypes may help in understanding cognitive decline and its relationship with brain changes in MS, providing insights for future research.
What this does not prove
The study's cross-sectional design limits the ability to draw causal conclusions about the relationship between cognitive phenotypes and brain changes. Additionally, the findings may not apply to all MS populations, as the sample was specific to the cohort studied.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 369 · basis not reported
- Randomised
- Not reported
- Controlled
- Yes
- Primary endpoint met
- Not reported
- Relevant MS type
- All
- Publication date
- 2026-10-15
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceFunctional and Structural Imaging Features of Cognitive Profiles in Multiple Sclerosis. ↗DOI: 10.1212/nxi.0000000000200669
Supporting passages (8)
study designMETHODS: We conducted an observational, cross-sectional study with right-handed patients with MS and age-matched and sex-matched healthy controls (HCs) who underwent neurologic and neuropsychological evaluation (Brief Repeatable Battery of Neuropsychological tests).
subjectsThree hundred and sixty-nine patients with MS and 168 HCs were enrolled.
sample sizeThree hundred and sixty-nine patients with MS and 168 HCs were enrolled.
controlledMETHODS: We conducted an observational, cross-sectional study with right-handed patients with MS and age-matched and sex-matched healthy controls (HCs) who underwent neurologic and neuropsychological evaluation (Brief Repeatable Battery of Neuropsychological tests).
relevant ms typesCognitive impairment affects 40%-70% of patients with multiple sclerosis (MS).
findingsFour cognitive phenotypes were detected: preserved cognition ([PC], n = 67[18.2%]), mild single-domain verbal fluency involvement (MSD-VF, n = 37[10.0%]), mild single-domain attention involvement (MSD-A, n = 197[53.4%]), and severe multidomain (SMD) involvement (SMD, n = 68[18.4%]).
publication datePublication date: 2026-10-15
limitationsTitle: Functional and Structural Imaging Features of Cognitive Profiles in Multiple Sclerosis.
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