MRI Findings in Progressive Multiple Sclerosis (Animal/Cell Subjects Unknown)
In a study of 106 people with progressive multiple sclerosis (PwPMS), 52% had at least one paramagnetic rim lesion (PRL). Of those, only 33% had definite PRLs. Probable PRLs were more common in secondary compared to primary progressive MS, and younger individuals had a higher count of PRLs and shorter disease duration.
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- #MSResearch
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Why it matters
These findings suggest a potential relationship between the presence and type of PRLs and age, as well as differences in disease type. Understanding PRLs could aid in assessing disease progression in MS.
What this does not prove
The observational nature of this study does not establish causality, and it does not clarify if changes in rim visibility affect clinical outcomes.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- 106 · PwPMS recruited for MRI assessment.
- Randomised
- No
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceReduced Paramagnetic Rim Visibility Signals Lesion Aging and Tissue Degeneration in Progressive Multiple Sclerosis: Impact on Clinical Trials. ↗DOI: 10.1212/nxi.0000000000200655
Supporting passages (7)
sample sizeOne hundred six PwPMS (34 primary progressive [PP], 72 secondary progressive; age 56 ± 10 years; median Expanded Disability Status Scale [EDSS] 5.5; 44% on disease-modifying therapy) underwent 3D-EPI and multishell diffusion MRI.
randomizedProbable PRLs were more frequent in secondary vs PP MS (24% vs 9%, p = 0.05).
sample size basisOne hundred six PwPMS (34 primary progressive [PP], 72 secondary progressive; age 56 ± 10 years; median Expanded Disability Status Scale [EDSS] 5.5; 44% on disease-modifying therapy) underwent 3D-EPI and multishell diffusion MRI.
findingsIn total, 52% of PwPMS had ≥1 PRL; only 33% had Definite PRLs.
findingsDefinite PRLs showed higher rim susceptibility (22 vs 8 ppb, p < 0.001); Probable PRLs demonstrated greater tissue disruption at qMRI-higher mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and FISO and lower neurite density index (NDI), and larger lesion size (all p < 0.001).
publication datePublication date: 2026-09-21
limitationsTitle: Reduced Paramagnetic Rim Visibility Signals Lesion Aging and Tissue Degeneration in Progressive Multiple Sclerosis: Impact on Clinical Trials.
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