AI CuratorAI-generated
Research summary · AI summary · not yet reviewedHuman studyObservationalPeer review unconfirmed
Combined Assessment of CVS and PRL in Patients with Multiple Sclerosis Misdiagnosis
In a study of 30 patients, those with confirmed MS demonstrated higher rates of CVS positivity (66.7%) and PRL positivity (53.3%) compared to misdiagnosed patients (13.3% and 0%, respectively). Combining both markers achieved 100% specificity but lowered sensitivity to 46.7%.
- Tags
- #Other
- Most relevant to
- —
This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
Why it matters
This study suggests that combining CVS and PRL assessments may help differentiate true MS from misdiagnosed cases, aiding in accurate diagnosis.
What this does not prove
The study is observational with a small sample size, limiting the generalizability of the findings and it does not set definitive diagnostic guidelines.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 30 · Total participants recruited (15 with confirmed MS and 15 misdiagnosed)
- Randomised
- Not reported
- Controlled
- Yes
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-10-03
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Other
Original sources
- Primary evidenceCombining the central vein sign and paramagnetic rim lesions in the evaluation of multiple sclerosis misdiagnosis. ↗DOI: 10.1016/j.msard.2026.107960
Supporting passages (13)
study designOBJECTIVES: To evaluate the diagnostic performance of CVS and PRLs, individually and in combination, for differentiating MS from patients misdiagnosed with MS in a prospectively recruited matched cohort study.
subjectsMETHODS: Thirty patients referred to a tertiary MS center with a neurologist-assigned diagnosis of MS were prospectively recruited after independent expert consensus adjudication: 15 with confirmed MS and 15 with an alternative non-MS diagnosis (misdiagnosed).
sample sizeMETHODS: Thirty patients referred to a tertiary MS center with a neurologist-assigned diagnosis of MS were prospectively recruited after independent expert consensus adjudication: 15 with confirmed MS and 15 with an alternative non-MS diagnosis (misdiagnosed).
sample size basisMETHODS: Thirty patients referred to a tertiary MS center with a neurologist-assigned diagnosis of MS were prospectively recruited after independent expert consensus adjudication: 15 with confirmed MS and 15 with an alternative non-MS diagnosis (misdiagnosed).
controlledOBJECTIVES: To evaluate the diagnostic performance of CVS and PRLs, individually and in combination, for differentiating MS from patients misdiagnosed with MS in a prospectively recruited matched cohort study.
primary endpoint metCONCLUSION: Combined CVS and PRL assessment may provide complementary, supportive evidence in diagnostically challenging cases vulnerable to misdiagnosis.
research categoriesBACKGROUND: Emerging imaging biomarkers such as the central vein sign (CVS) and paramagnetic rim lesion (PRL) have high diagnostic specificity for multiple sclerosis (MS).
publication datePublication date: 2026-10-03
interventionCONCLUSION: Combined CVS and PRL assessment may provide complementary, supportive evidence in diagnostically challenging cases vulnerable to misdiagnosis.
comparatorMETHODS: Thirty patients referred to a tertiary MS center with a neurologist-assigned diagnosis of MS were prospectively recruited after independent expert consensus adjudication: 15 with confirmed MS and 15 with an alternative non-MS diagnosis (misdiagnosed).
primary endpointMeasures of diagnostic performance, including sensitivity and specificity, were calculated for CVS (Select6* criteria) and PRLs (≥1) as standalone and combined biomarkers.
findingsRequiring both biomarkers yielded 100% specificity but reduced sensitivity (46.7%, 95% CI: 21.4-71.9%).
limitationsTitle: Combining the central vein sign and paramagnetic rim lesions in the evaluation of multiple sclerosis misdiagnosis.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.