Bone Marrow Analysis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis Mice
In a study involving treatment-naive MS patients and EAE mice, MS bone marrow exhibited myeloid skewing and a mixed transcriptional state resembling PMN-MDSCs. Findings indicated increased neutrophil degranulation and an ARG1-associated network. In EAE, administering nor-NOHA showed reduced clinical scores and spinal cord damage, suggesting a potential link between this compound and immune modulation in MS.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
Understanding the myeloid skewing in MS bone marrow and the impact of compounds like nor-NOHA on EAE models may provide insights into immune dysfunctions in MS.
What this does not prove
The true nature of the PMN-MDSC-like state in MS bone marrow remains uncertain, necessitating more investigations to explore these findings further, especially across species.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-14
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- treatment-naive patients with MS
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceAn ARG1-associated immunometabolic program in bone marrow PMN-MDSC-like cells in multiple sclerosis and experimental autoimmune encephalomyelitis. ↗DOI: 10.3389/fimmu.2026.1924483
Supporting passages (7)
publication date2026-10-14
interventionnor-NOHA
limitationsHowever, whether MS bone marrow contains an immunometabolic PMN-MDSC-like state, and whether related ARG1-associated observations can be examined in a cross-species EAE context, remains unclear.
populationtreatment-naive patients with MS
findingsRESULTS: MS bone marrow showed myeloid skewing and a heterogeneous PMN-MDSC-like transcriptional state, while donor-level subtype proportions were comparable between groups. Neutrophil degranulation showed the strongest BH-supported donor-pseudobulk enrichment, and expression-based regulatory and communication analyses converged on an ARG1-associated network. In EAE, flow-gated bone-marrow PMN-MDSCs and ARG1 protein were increased, and systemic prophylactic nor-NOHA was associated with lower clinical scores and reduced spinal-cord pathology.
peer reviewedPublication types: Journal Article
subjectsMeSH terms: Encephalomyelitis, Autoimmune, Experimental; Arginase; Animals; Humans; Multiple Sclerosis; Female; Mice; Neutrophils; Adult; Male; Mice, Inbred C57BL
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