Microglial Ferroptosis in White Matter Injury: Implications for MS and Other Diseases
This systematic review discusses how microglial ferroptosis contributes to myelin repair failure in white matter injuries related to diseases including multiple sclerosis (MS). It highlights mechanisms like iron dysregulation and lipid peroxidation that influence microglial susceptibility to ferroptosis.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding microglial ferroptosis can shed light on myelin repair processes in MS, potentially guiding future research on therapeutic strategies for myelin repair in neurological diseases.
What this does not prove
The review does not confirm a direct causal link between microglial ferroptosis and specific MS outcomes and is based on summarized evidence rather than clinical trials.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-30
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceFrom scavenger to victim: mechanism and treatment of microglial ferroptosis in white matter injury disease. ↗DOI: 10.3389/fimmu.2026.1859981
Supporting passages (6)
study designThis review summarizes current evidence on the molecular mechanisms, multicellular interactions, microglial states, disease contexts, and therapeutic strategies associated with microglial ferroptosis in WMI.
peer reviewedJournal: Frontiers in immunology
findingsFailure of myelin repair is a shared pathological feature of white matter injury (WMI)-associated diseases, including Alzheimer's disease (AD), vascular dementia (VaD), and multiple sclerosis (MS), but the underlying mechanisms remain incompletely understood.
findingsThis susceptibility is regulated by interconnected mechanisms involving ferritinophagy-associated iron dysregulation, ACSL4/NOX2/15-LOX-related lipid peroxidation, and impaired endogenous ferroptosis-defense systems.
publication datePublication date: 2026-09-30
limitationsTitle: From scavenger to victim: mechanism and treatment of microglial ferroptosis in white matter injury disease.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.