Patient-Reported Measurements in Older People with MS
In a study involving older adults (55+) with MS, a larger percentage reported decreased physical abilities over time, such as difficulty getting up from a sofa and standing for more than 30 minutes. Meanwhile, improvements were noted in psychosocial areas including reduced pessimism and feelings of tension.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
These findings highlight the complex nature of health in older adults with MS, showing deteriorating physical capacities alongside improved mental well-being. This dual observation can inform future studies on MS management in aging populations.
What this does not prove
The study is observational and based on self-reported data, which may not accurately capture all factors. Additionally, the effect of aging on reported outcomes for people with MS is not fully understood.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2025-10-20
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- People with MS 55 years and older enrolled in the NYSMSC
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceLong-Term Changes in Patient-Reported Outcome Measures in People With Multiple Sclerosis 55 Years and Older: Analysis From the New York State Multiple Sclerosis Consortium. ↗DOI: 10.7224/1537-2073.2024-067
Supporting passages (8)
publication datePublication date: 2025-10-20
populationMETHODS: Included in the analysis were people with MS enrolled in the New York State Multiple Sclerosis Consortium (NYSMSC), 55 years or older, with at least 3 clinical visits recorded in the consortium database.
findingsRESULTS: Of 658 eligible people in the NYSMSC (mean age at most recent follow-up, 66.6 years), a greater percentage reported decreased ability since baseline in all physical PROMs domains (getting up from sofa, 38.4% to 48.8%, P < .001; standing for more than 30 minutes, 59.3% vs 66.9%, P < .001; and functional limitations in all extremities, P < .007).
findingsContrarily, the group reported improvement in multiple psychosocial domains, including pessimism (P < .001), feeling tense (P < .001), feeling annoyed (P = .02), or having morbid thoughts (P = .018).
findingsPeople with increasing disability had significantly worse baseline physical PROMs when compared with people with stable MS.
limitationsTitle: Long-Term Changes in Patient-Reported Outcome Measures in People With Multiple Sclerosis 55 Years and Older: Analysis From the New York State Multiple Sclerosis Consortium.
peer reviewedPublication types: Journal Article
subjectsTitle: Long-Term Changes in Patient-Reported Outcome Measures in People With Multiple Sclerosis 55 Years and Older: Analysis From the New York State Multiple Sclerosis Consortium.
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