Ginkgo Biloba Extract (GBE) and Inflammation in Human Studies
A systematic review found that Ginkgo biloba extract (GBE) reduces inflammation by lowering pro-inflammatory cytokines, inhibiting NF-κB activation, and improving redox balance, suggesting potential relevance for multiple sclerosis among other diseases.
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Why it matters
The findings support GBE's role in managing inflammation, which is crucial in various conditions like multiple sclerosis. However, much remains unknown about GBE's specific active components and standardized formulations needed for effective treatment.
What this does not prove
There is a lack of clarity on specific active compounds in GBE and issues with formulation standardization. Furthermore, robust clinical evidence and large-scale studies are necessary to establish safety and efficacy.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-01
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidencePotential of Ginkgo biloba Extract to Intervene in Chronic Inflammation-Related Diseases. ↗DOI: 10.1002/ptr.70467
Supporting passages (6)
study designThis review comprehensively summarizes the current preclinical and clinical evidence regarding the therapeutic potential of GBE and its active constituents in inflammation-related diseases.
subjectsThis review comprehensively summarizes the current preclinical and clinical evidence regarding the therapeutic potential of GBE and its active constituents in inflammation-related diseases.
peer reviewedGinkgo biloba extract (GBE), a standardized formulation derived from Ginkgo biloba leaves, has attracted growing attention due to its anti-inflammatory, antioxidant, and neuroprotective properties.
findingsGBE has been shown to attenuate pro-inflammatory cytokine production, suppress nuclear factor kappa B (NF-κB) activation, restore redox homeostasis, and modulate disease-relevant pathways in models of Alzheimer's disease, Parkinson's disease, multiple sclerosis, atherosclerosis, asthma, chronic obstructive pulmonary disease, inflammatory bowel disease, inflammatory skin conditions and rheumatoid arthritis.
limitationsWhile these findings highlight the promising multi-targeted anti-inflammatory actions of GBE, limitations remain regarding the identification of specific active compounds, standardization of formulations, and the availability of robust clinical evidence.
publication datePublication date: 2026-10-01
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.