Mice show gadolinium accumulation and mitochondrial changes due to neuroinflammation
In EAE mice, neuroinflammation led to increased hippocampal gadolinium (Gd) accumulation after using gadolinium-based contrast agents (GBCAs). Long-term Gd retention was particularly notable for gadopentetate. Low-to-intermediate GBCA concentrations caused reductions in mitochondrial length and area, and high gadopentetate concentrations impaired mitochondrial motility, suggesting inflammation exacerbates mitochondrial issues without affecting Gd levels in tissue slices.
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Why it matters
Understanding how neuroinflammation affects Gd accumulation and mitochondrial health in the brain may provide insights for neurological conditions. However, findings from animal models like this one cannot be directly applied to human multiple sclerosis cases.
What this does not prove
The study was conducted in an animal model and does not directly apply to human multiple sclerosis.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceGadolinium-based Contrast Agents Trigger Gadolinium Accumulation Within the Hippocampus In Vivo and Mitochondrial Alterations in Organotypic Hippocampal Tissue Cultures Ex Vivo. ↗DOI: 10.1097/rli.0000000000001315
Supporting passages (4)
speciesMice
publication date2026-09-21
findingsRESULTS: In vivo, neuroinflammation increased hippocampal Gd accumulation following administration of both GBCAs in EAE mice.
limitationsTitle: Gadolinium-based Contrast Agents Trigger Gadolinium Accumulation Within the Hippocampus In Vivo and Mitochondrial Alterations in Organotypic Hippocampal Tissue Cultures Ex Vivo.
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