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Research summary · 2 h ago

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Gamma Knife Radiosurgery Outcomes in Multiple Sclerosis-Associated Trigeminal Neuralgia: Data from 248 Patients

In a retrospective analysis of 248 multiple sclerosis patients with trigeminal neuralgia, 62.8% experienced early pain relief. However, 41.7% of those who responded had a recurrence of pain, and 9.9% developed facial hypoesthesia. Higher trigeminal root V%BED1000 was linked to better early pain relief and lower recurrence, while greater BED coverage related to more durable pain control.

Tags: #MSResearch
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Source: Read original source (PMID 42846713)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Why it matters

These findings suggest potential predictors for pain relief and recurrence in patients undergoing Gamma Knife surgery, potentially guiding future treatment strategies.

What this does not prove

The study's retrospective design may overlook confounding factors, and causal relationships cannot be definitively established. Variability in individual responses to treatment and other unmeasured factors may influence outcomes.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Not reported
Participants / samples: 248 · basis not reported
Randomised: Not reported
Controlled: Not reported
Primary endpoint met: Yes
Relevant MS type: Not reported
Publication date: 2026-10-08
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Not classified

Original sources

Primary evidenceDivision Specific Biologically Effective Dose Predicts Gamma Knife Radiosurgery Outcomes in Multiple Sclerosis-Associated Trigeminal Neuralgia. ↗DOI: 10.1227/neuprac.0000000000000304

Supporting passages (5)

sample sizeWe retrospectively analyzed data from 248 patients with medically refractory MS-TN1 who were treated with GKS between 2012 and 2024.

primary endpoint metEarly pain relief occurred in 156 patients (62.8%).

findingsFacial hypoesthesia developed in 25 patients (9.9%).

publication datePublication date: 2026-10-08

limitationsTitle: Division Specific Biologically Effective Dose Predicts Gamma Knife Radiosurgery Outcomes in Multiple Sclerosis-Associated Trigeminal Neuralgia.

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