Human Study on Glutamate in MS Lesions
In a study involving 20 participants with multiple sclerosis, it was found that glutamate-weighted contrast was 10.7% higher in paramagnetic rim lesions compared to non-paramagnetic rim lesions and 13% higher compared to normal-appearing white matter. Lower contrast in normal-appearing tissues was connected to poorer motor function and dexterity.
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- #MSResearch
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Why it matters
These findings suggest that glutamate levels may vary significantly in different types of MS lesions and could be linked to clinical disability.
What this does not prove
The observational nature of the study means it cannot prove causation. The specific biochemical mechanisms at play are not fully understood.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-08-10
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceAltered Glutamate Homeostasis in Paramagnetic Rim Lesions of Patients with Multiple Sclerosis. ↗DOI: 10.64898/2026.08.06.26359875
Supporting passages (6)
subjectsGlutamate-weighted chemical exchange saturation transfer, together with T 1 mapping and quantitative susceptibility mapping, was evaluated across paramagnetic rim lesions, non-paramagnetic rim lesions, and normal-appearing tissues in participants with multiple sclerosis (n=20) and healthy controls (n=11).
publication datePublication date: 2026-08-10
comparatorGlutamate-weighted chemical exchange saturation transfer contrast was significantly higher in paramagnetic rim lesions compared to non-paramagnetic rim lesions (+10.7%) and normal-appearing white matter (+13%), while no differences were observed in normal-appearing tissue between multiple sclerosis and healthy controls.
primary endpointAdditionally, reduced glutamate-weighted chemical exchange saturation transfer contrast in normal-appearing tissues was associated with worse motor and dexterity performance, linking observed metabolic abnormalities to clinical disability.
findingsGlutamate-weighted chemical exchange saturation transfer contrast was significantly higher in paramagnetic rim lesions compared to non-paramagnetic rim lesions (+10.7%) and normal-appearing white matter (+13%), while no differences were observed in normal-appearing tissue between multiple sclerosis and healthy controls.
limitationsTitle: Altered Glutamate Homeostasis in Paramagnetic Rim Lesions of Patients with Multiple Sclerosis.
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