Cognitive Performance and Psychological Characteristics in Patients With Clinically Isolated Syndrome
A study found that patients with Clinically Isolated Syndrome (CIS) had worse cognitive performance and higher levels of depression, anxiety, and obsessive beliefs compared to healthy controls. CIS patients scored significantly lower on cognitive tests assessing motor, attention, memory, and executive functions (p < 0.05).
- Tags
- #ImmuneReset
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
These findings highlight the psychological and cognitive challenges faced by patients with CIS, which may impact their quality of life and require further investigation into supportive interventions.
What this does not prove
CIS patients in the study exhibited mild neurological disability, potentially limiting the findings' relevance to all MS patients. Moreover, there was no long-term follow-up to assess the progression of cognitive and psychological changes.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Case report
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-13
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Immune reset, Neuroinflammation, Other
Original sources
- Primary evidenceCognitive Performance and Psychological Characteristics in Patients With Clinically Isolated Syndrome: A Case-Control Study. ↗DOI: 10.1002/hsr2.73391
Supporting passages (9)
study phaseThis study evaluated cognitive performance and psychological characteristics in patients with CIS and healthy individuals.
study designMETHODS: This case-control study enrolled 80 patients with CIS and 80 healthy controls matched for age and sex (mean age 34 years; 48 women per group) at Golestan Hospital (Ahvaz, Iran).
subjectsMETHODS: This case-control study enrolled 80 patients with CIS and 80 healthy controls matched for age and sex (mean age 34 years; 48 women per group) at Golestan Hospital (Ahvaz, Iran).
sample size basisMETHODS: This case-control study enrolled 80 patients with CIS and 80 healthy controls matched for age and sex (mean age 34 years; 48 women per group) at Golestan Hospital (Ahvaz, Iran).
research categoriesThis study evaluated cognitive performance and psychological characteristics in patients with CIS and healthy individuals.
publication datePublication date: 2026-10-13
primary endpointThis study evaluated cognitive performance and psychological characteristics in patients with CIS and healthy individuals.
findingsMean scores for depression, anxiety, and obsessive beliefs were significantly higher in patients with CIS than in controls (p < 0.05).
limitationsTitle: Cognitive Performance and Psychological Characteristics in Patients With Clinically Isolated Syndrome: A Case-Control Study.
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