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Association Between Foot Alterations and Disability in People With Multiple Sclerosis: A Cross-Sectional Study
A study of 100 individuals with MS found that plantar tactile sensory loss was independently linked to higher disability levels measured by EDSS. Additionally, factors like anxiety and occupational inactivity were also noted to influence disability outcomes.
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This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
Why it matters
These findings highlight the impact of foot health on mobility and overall quality of life in MS patients, stressing the need for multidisciplinary care that includes podiatric assessments.
What this does not prove
The study is cross-sectional, making it difficult to determine causation from the observed associations.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 100 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-09-23
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Other
Original sources
- Primary evidenceAssociation Between Foot Alterations and Disability in People With Multiple Sclerosis: A Cross-Sectional Study. ↗DOI: 10.1177/19386400261484267
Supporting passages (10)
study designWhile gait and lower limb dysfunction are well studied, foot- and ankle-specific impairments remain underexplored despite their potential impact on mobility, independence, and quality of life.ObjectiveTo examine the relationship between foot alterations and functional disability in MS using the Expanded Disability Status Scale (EDSS).MethodsA cross-sectional study was conducted in an endocrinology outpatient clinic and MS associations.
subjectsMultiple linear regression was applied to identify predictors of disability.ResultsOne hundred individuals with MS participated; 78% were women.
sample sizeMultiple linear regression was applied to identify predictors of disability.ResultsOne hundred individuals with MS participated; 78% were women.
peer reviewedFindings underscore the need for podiatric assessment within multidisciplinary care to help preserve mobility and quality of life.
primary endpoint metIn multivariate analysis, absent tactile sensitivity (β = 0.142, P = .004), anxiety (β = 0.838, P = .013), and occupational inactivity (β = 0.359, P = .057) emerged as significant predictors.ConclusionPlantar tactile sensory loss was the only podiatric factor independently associated with disability in MS, with anxiety and occupational inactivity also contributing.
research categoriesFindings underscore the need for podiatric assessment within multidisciplinary care to help preserve mobility and quality of life.
publication datePublication date: 2026-09-23
primary endpointTo examine the relationship between foot alterations and functional disability in MS using the Expanded Disability Status Scale (EDSS).
findingsIn multivariate analysis, absent tactile sensitivity (β = 0.142, P = .004), anxiety (β = 0.838, P = .013), and occupational inactivity (β = 0.359, P = .057) emerged as significant predictors.ConclusionPlantar tactile sensory loss was the only podiatric factor independently associated with disability in MS, with anxiety and occupational inactivity also contributing.
limitationsTitle: Association Between Foot Alterations and Disability in People With Multiple Sclerosis: A Cross-Sectional Study.
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