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Research summary · AI summary · not yet reviewedHuman studyNot reportedTrial registry record – peer review not applicable
Effects of Local Vibration vs. Ankle Joint Mobilization on Muscle Tone and Balance in Individuals with MS
The study is designed to compare local mechanical vibration and ankle joint mobilization effects on muscle tone and proprioception in multiple sclerosis patients. Participants will be randomly assigned to one of these interventions for six weeks, assessing changes in ankle joint position sense error before and after treatment.
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- #Rehabilitation
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This plain-English summary was written by AI from a trial registry record and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding these interventions could improve rehabilitation strategies for those with MS, potentially enhancing balance and functional mobility.
What this does not prove
No results are currently available, and the inclusion of planned endpoints does not indicate findings.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- All
- Publication date
- Not reported
- Evidence reviewed
- Trial registry record
- Regulatory approval
- No
- Research areas
- Rehabilitation
Original sources
- Trial registrationLocal Vibration and Ankle Mobilization in Multiple Sclerosis ↗
Supporting passages (10)
subjects"eligibilityCriteria": "Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Diagnosis of multiple sclerosis confirmed by a neurologist.\n* Expanded Disability Status Scale (EDSS) score ≤6.0.\n* Ability to walk at least 100 meters, with or without an assistive device.\n* No MS relapse within the previous 3 months.\n* Willingness to participate in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* MS relapse within the previous 3 months.\n* Severe cognitive impairment or cognitive problems that may interfere with communication or participation.\n* History of orthopedic surgery involving the lower extremity or presence of a severe orthopedic condition affecting lower-extremity function.\n* Vestibular system disorder or another neurological condition that may affect balance.\n* Any medical condition contraindicating local vibration or manual therapy.\n* Inability to participate regularly throughout the study period.",
regulatory approval"isFdaRegulatedDevice": false
research categories"briefSummary": "This study will investigate the effects of local vibration and ankle joint mobilization on muscle tone, proprioception, and balance in individuals with multiple sclerosis (MS).
relevant ms types"eligibilityCriteria": "Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Diagnosis of multiple sclerosis confirmed by a neurologist.\n* Expanded Disability Status Scale (EDSS) score ≤6.0.\n* Ability to walk at least 100 meters, with or without an assistive device.\n* No MS relapse within the previous 3 months.\n* Willingness to participate in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* MS relapse within the previous 3 months.\n* Severe cognitive impairment or cognitive problems that may interfere with communication or participation.\n* History of orthopedic surgery involving the lower extremity or presence of a severe orthopedic condition affecting lower-extremity function.\n* Vestibular system disorder or another neurological condition that may affect balance.\n* Any medical condition contraindicating local vibration or manual therapy.\n* Inability to participate regularly throughout the study period.",
interventionLocal mechanical vibration applied to the medial and lateral heads of the gastrocnemius muscle at 40 Hz, 3 minutes per muscle head, three times per week for six weeks.
comparatorGrade III posterior-to-anterior talocrural joint mobilization, 60 seconds per set with 30 seconds rest, 4 sets per session, three times per week for six weeks.
primary endpointAnkle Joint Position Sense Error
follow up"timeFrame": "Baseline and immediately after the 6-week intervention"
findingsParticipants will be randomly assigned to one of two treatment groups.
limitationsPlanned enrolment and endpoints are not findings.
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