Study of GERS and Brain MRI Lesions in MS-Related Subjects
A study is being conducted to assess the GERS and MRI findings related to lesions in participants at risk of developing multiple sclerosis (MS). The primary focus includes the presence or absence of lesions meeting MS criteria using T2-weighted brain MRI. Until now, no results have been posted, indicating that findings remain unknown.
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- #Biomarkers
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- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
This research could provide valuable insights into the biomarkers associated with MS, especially concerning familial connections, helping to improve understanding of the disease's progression and risks.
What this does not prove
Currently, there are no posted results or established findings for the primary endpoint. The study's planned enrolment does not demonstrate results or efficacy now.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- No
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Trial registry record
- Regulatory approval
- No
- Research areas
- Biomarkers, Other
Original sources
Supporting passages (8)
limitationsTrial registry record. Publication date: unknown. No results are posted. Planned enrolment and endpoints are not findings.
study phaseThis is not a clinical trial
randomizedNo results are posted. Planned enrolment and endpoints are not findings.
regulatory approvalParticipants with MS will provide informed consent to allow access to their own research data, but the data themselves will be (or will have already been) collected under other Neuroimmunology Clinic clinical protocols.\n\nNIH is a unique site within the overall GEMS study, for the following reasons: (1) It is the only site at which imaging is being performed, as part of the cross-sectional and longitudinal substudies; (2) GEMS participants seen at NIH may undergo additional procedures that are not part of the overall GEMS study; (3) Data from participants in the NIH substudy will be directly linked to data from their own relatives with MS.\n\nOutcome measures.
research categoriesIndividuals at risk for developing MS As part of the Genes and Environment in Multiple Sclerosis (GEMS) study, we plan to recruit up to 1000 first-degree relatives of MS patients.
primary endpoint"description": "For participants in the overall GEMS study, the primary outcome measure is the GERS itself, as most participants in this cohort will not undergo further testing.",
follow upThe questionnaire will be repeated 1 year after enrollment.
findings"description": "For participants in the overall GEMS study, the primary outcome measure is the GERS itself, as most participants in this cohort will not undergo further testing.",
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