AI CuratorAI-generated
Research summary · AI summary · not yet reviewedHuman studyObservationalPublished in a peer-reviewed journal
Lower ALPS-index in Human Individuals with Relapsing-Remitting MS
Individuals with relapsing-remitting multiple sclerosis (RRMS) were found to have a significantly lower ALPS-index compared to non-MS controls (p = 0.001). Additionally, both lower ALPS-index and slower gait speed were independently associated with longer disease duration in RRMS patients (p = 0.028).
- Most relevant to
- —
This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
These findings indicate that the ALPS-index may be a useful imaging marker for age-related vulnerability and its relationship with mobility and aging in MS.
What this does not prove
The study does not establish causation between ALPS-index and disease duration. Results are limited to RRMS patients and a specific age- and sex-matched control group, which may affect generalization.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- Not reported
- Randomised
- No
- Controlled
- Yes
- Primary endpoint met
- Yes
- Relevant MS type
- RRMS
- Publication date
- 2026-10-04
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Neuroinflammation, Other
Original sources
- Primary evidenceReduced perivascular diffusion in multiple sclerosis is associated with aging, disease duration, and mobility impairment. ↗DOI: 10.1016/j.msard.2026.107958
Supporting passages (13)
study designThe objectives of this study were to: (1) compare the ALPS-index between individuals with relapsing-remitting MS (RRMS) and non-MS controls, (2) examine the role of age in the association between ALPS-index and disease duration, and (3) examine the relationship between ALPS-index and walking speed in RRMS.
subjectsMETHODS: Individuals with RRMS and age‑ and sex-matched controls underwent 3T MRI, including diffusion‑weighted imaging.
randomizedMETHODS: Individuals with RRMS and age‑ and sex-matched controls underwent 3T MRI, including diffusion‑weighted imaging.
controlledMETHODS: Individuals with RRMS and age‑ and sex-matched controls underwent 3T MRI, including diffusion‑weighted imaging.
peer reviewedJournal: Multiple sclerosis and related disorders
primary endpoint metIndividuals with RRMS have significantly lower ALPS‑index compared to controls (p = 0.001).
research categoriesCONCLUSIONS: These findings highlight the interconnected roles of aging, perivascular fluid transport, and mobility in MS and support the ALPS‑index as a feasible, non‑invasive imaging marker of age‑related vulnerability.
relevant ms typesThe objectives of this study were to: (1) compare the ALPS-index between individuals with relapsing-remitting MS (RRMS) and non-MS controls, (2) examine the role of age in the association between ALPS-index and disease duration, and (3) examine the relationship between ALPS-index and walking speed in RRMS.
publication datePublication date: 2026-10-04
comparatorRESULTS: Individuals with RRMS have significantly lower ALPS‑index compared to controls (p = 0.001).
primary endpointThe objectives of this study were to: (1) compare the ALPS-index between individuals with relapsing-remitting MS (RRMS) and non-MS controls, (2) examine the role of age in the association between ALPS-index and disease duration, and (3) examine the relationship between ALPS-index and walking speed in RRMS.
findingsIn a multivariable model, both lower ALPS‑index and slower gait speed were independently associated with longer disease duration, with an interaction effect (p = 0.032) suggesting functional compensation between perivascular diffusion and mobility.
limitationsTitle: Reduced perivascular diffusion in multiple sclerosis is associated with aging, disease duration, and mobility impairment.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.