Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis (Human Study)
A meta-analysis found that the prevalence of schizophrenia (SCZ) in people with multiple sclerosis (MS) was 0.61%, while the prevalence of bipolar disorder (BD) was 3.34%. Prevalence rates varied based on factors such as disease stage, disability level, sex ratio, and geographic location, with higher rates reported in the Americas and Europe. The study period also influenced these prevalences.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Moderate
- Outcome
- Not reported
Why it matters
Understanding the prevalence of SCZ and BD in MS patients is crucial for improving mental health support and healthcare planning. Variations by sex and disease stage suggest the need for tailored interventions.
What this does not prove
The study emphasizes the necessity for standardized assessments and additional research to refine these prevalence estimates.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Meta-analysis
- Participants / samples
- Not reported
- Randomised
- Not applicable
- Controlled
- Not applicable
- Primary endpoint met
- Not applicable
- Relevant MS type
- All
- Publication date
- 2026-10-19
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceThe Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis: A Systematic Review and Meta-Analysis. ↗DOI: 10.7224/1537-2073.2026-005
Supporting passages (11)
subjectsOur aim was to determine the global pervasiveness of SCZ and BD in people with MS.
peer reviewedPublication types: Journal Article
relevant ms typesThe prevalence of BD was higher in people with early-stage MS or moderate disability and varied by sex ratio.
publication datePublication date: 2026-10-19
findingsThe pooled prevalence of SCZ in people with MS was 0.61% (95% CI, 0.25%-1.11%), and BD was 3.34% (95% CI, 2.04%-4.91%).
limitationsThese findings highlight the need for standardized assessments and further studies.
study designTitle: The Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
study phaseTitle: The Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
randomizedTitle: The Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
controlledTitle: The Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
primary endpoint metTitle: The Prevalence of Schizophrenia and Bipolar Disorder in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
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