Seizures in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): Insights from a Systematic Review
A systematic review examined the prevalence and types of seizures associated with MOGAD, finding about 30% occurrence in pediatric cases versus 7% in adults. Different seizure forms were identified, including links to cortical neuroimmunology and ADEM-associated seizures.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Moderate
- Outcome
- Not reported
Why it matters
Understanding seizure prevalence in MOGAD can improve diagnosis and management strategies for affected individuals, particularly in pediatric populations where seizures are more common.
What this does not prove
The prevalence estimates may be skewed due to referral and publication biases, suggesting that the actual rates could differ from reported figures.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not applicable
- Controlled
- Not applicable
- Primary endpoint met
- Not applicable
- Relevant MS type
- Not reported
- Publication date
- 2026-10-06
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceSeizures and epilepsy in MOG antibody-associated disease: from cortical neuroimmunology to clinical practice. ↗DOI: 10.3389/fimmu.2026.1966487
Supporting passages (10)
study designPublication types: Journal Article; Review
subjectsMeSH terms: Humans; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease; Epilepsy; Myelin-Oligodendrocyte Glycoprotein; Seizures; Autoantibodies; Animals
peer reviewedPublication types: Journal Article; Review
publication datePublication date: 2026-10-06
findingsTheir reported prevalence is strongly age-dependent-approximately 30% in pediatric-onset versus 7% in adult-onset cohorts, although these estimates are influenced by referral and publication bias-and clusters around cerebral cortical encephalitis (CCE) and FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES).
limitationsTheir reported prevalence is strongly age-dependent-approximately 30% in pediatric-onset versus 7% in adult-onset cohorts, although these estimates are influenced by referral and publication bias-and clusters around cerebral cortical encephalitis (CCE) and FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES).
study phasePublication types: Journal Article; Review
randomizedPublication types: Journal Article; Review
controlledPublication types: Journal Article; Review
primary endpoint metPublication types: Journal Article; Review
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.