Brain Volume Loss in Patients with Radiologically Isolated Syndrome
In a study involving 28 human patients with Radiologically Isolated Syndrome, researchers observed significant annual losses in total brain volume and specific regions, including the cerebrum and thalamus, indicating potential neurodegenerative changes (p-values ranging from 0.033 to 0.047).
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
This finding is important as it suggests that patients with Radiologically Isolated Syndrome may experience notable brain atrophy over time, highlighting the need for ongoing monitoring and further research into disease progression.
What this does not prove
The study's observational design limits conclusions about causality, and most earlier research had focused on cross-sectional rather than longitudinal data, restricting understanding of how neurodegeneration develops over time.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 28 · basis not reported
- Randomised
- No
- Controlled
- No
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-09
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- patients with Radiologically Isolated Syndrome
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceTemporal Change: Evaluation of Brain Atrophy in Patients with Radiologically Isolated Syndrome Using volBrain. ↗DOI: 10.3390/medicina62101948
Supporting passages (12)
subjectsHuman
speciesHuman
sample size28
randomizedNo
controlledNo
publication date2026-10-09
populationTitle: Temporal Change: Evaluation of Brain Atrophy in Patients with Radiologically Isolated Syndrome Using volBrain.
findingsAfter correction for multiple comparisons using the Benjamini-Hochberg false discovery rate (FDR) procedure, significant annual volume loss was observed in total brain volume (p = 0.043), total cerebrum volume (p = 0.033), right cerebrum volume (p = 0.033), left cerebrum volume (p = 0.044), total thalamic volume (p = 0.033), right thalamic volume (p = 0.047), and left thalamic volume (p = 0.043).
limitationsHowever, most previous studies have employed cross-sectional designs, limiting the ability to characterize the temporal evolution of neurodegenerative changes.
peer reviewedPublication types: Journal Article
subjectsMeSH terms: Humans; Female; Magnetic Resonance Imaging; Atrophy; Brain; Male; Retrospective Studies; Adult; Middle Aged; Multiple Sclerosis; Demyelinating Diseases; Longitudinal Studies; Disease Progression
study designMeSH terms: Humans; Female; Magnetic Resonance Imaging; Atrophy; Brain; Male; Retrospective Studies; Adult; Middle Aged; Multiple Sclerosis; Demyelinating Diseases; Longitudinal Studies; Disease Progression
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