Rutin Effects on C57BL/6 Mice with Cuprizone-Induced Demyelination
In a study using C57BL/6 mice, rutin improved motor coordination deficits caused by cuprizone treatment in a dose-dependent manner. It also reduced demyelination in the corpus callosum and activated Nrf2 signaling while inhibiting the NF-κB pathway.
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- #MSResearch
- Most relevant to
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- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
These findings suggest that rutin may protect against motor coordination deficits and demyelination in a mouse model, highlighting its potential therapeutic value in neurological conditions associated with demyelination.
What this does not prove
This study is conducted on an animal model and does not establish efficacy in humans. It does not provide information on long-term effects or clinical applicability.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Laboratory
- Participants / samples
- Not reported
- Randomised
- No
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceRutin attenuates cuprizone-induced demyelination in C57BL/6 mice through activation of Nrf2 signaling and inhibition of NF-κB. ↗DOI: 10.22038/ijbms.2026.93649.20195
Supporting passages (8)
study phaseThis study investigated the therapeutic potential of rutin, a natural flavonoid, in a cuprizone (CPZ)-induced mouse model of demyelination.
study designThis study investigated the therapeutic potential of rutin, a natural flavonoid, in a cuprizone (CPZ)-induced mouse model of demyelination.
subjectsMATERIALS AND METHODS: Male C57BL/6 mice were fed a 0.2% CPZ diet for six weeks to induce central nervous system demyelination and were concurrently treated with rutin (50 or 100 mg/kg, intraperitoneally, for the last 14 days).
speciesMATERIALS AND METHODS: Male C57BL/6 mice were fed a 0.2% CPZ diet for six weeks to induce central nervous system demyelination and were concurrently treated with rutin (50 or 100 mg/kg, intraperitoneally, for the last 14 days).
randomizedMATERIALS AND METHODS: Male C57BL/6 mice were fed a 0.2% CPZ diet for six weeks to induce central nervous system demyelination and were concurrently treated with rutin (50 or 100 mg/kg, intraperitoneally, for the last 14 days).
primary endpointBehavioral tests revealed that rutin dose-dependently improved CPZ-induced motor coordination deficits in the pole, rotarod, and open-field tests.
findingsBehavioral tests revealed that rutin dose-dependently improved CPZ-induced motor coordination deficits in the pole, rotarod, and open-field tests.
limitationsTitle: Rutin attenuates cuprizone-induced demyelination in C57BL/6 mice through activation of Nrf2 signaling and inhibition of NF-κB.
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