Monoclonal Antibodies in Animal and Human Research
The review discusses monoclonal antibodies that have been developed as versatile research tools for cytokine detection and purification. These antibodies have helped in discovering unknown cytokine receptors, advancing research in cytokine biology.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Demonstrated in people
- Mechanism
- Not reported
- Evidence strength
- Moderate
- Outcome
- Positive
Why it matters
These findings are significant because they contribute to a better understanding of cytokine interactions, which are important in diseases like multiple sclerosis and other autoimmune disorders. This research broadens the scope for future studies in treatment options.
What this does not prove
The review does not provide specific trials or primary endpoint results related to the application of monoclonal antibodies for MS.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not applicable
- Controlled
- Not applicable
- Primary endpoint met
- Not applicable
- Relevant MS type
- All
- Publication date
- Not reported
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceReview Article: A Scientific Journey with Zelig Eshhar at the Dawn of Monoclonal Antibody Research. ↗DOI: 10.1615/critrevoncog.2026066174
Supporting passages (12)
findingsThese antibodies proved to be remarkably versatile research tools, suitable for neutralization, affinity chromatography, immunoassays, flow cytometry, immunoblotting, and numerous other applications.
study designPublication types: Journal Article; Review; Historical Article
subjectsMeSH terms: Humans; Antibodies, Monoclonal; History, 20th Century; History, 21st Century; Animals; Immunotherapy; Neoplasms
relevant ms typesthe treatment of autoimmune, inflammatory, and genetic diseases, such as multiple sclerosis, rheumatoid arthritis and Crohn's disease.
outcomeTogether, these unique reagents formed the foundation of a ligand-affinity strategy that led to the discovery of previously unknown cytokine receptors and binding proteins.
human efficacyenabled the affinity purification of in-house corresponding recombinant cytokines.
limitationsTitle: Review Article: A Scientific Journey with Zelig Eshhar at the Dawn of Monoclonal Antibody Research.
peer reviewedPublication types: Journal Article; Review; Historical Article
study phasePublication types: Journal Article; Review; Historical Article
randomizedPublication types: Journal Article; Review; Historical Article
controlledPublication types: Journal Article; Review; Historical Article
primary endpoint metPublication types: Journal Article; Review; Historical Article
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.