Cognitive Neurorehabilitation in Multiple Sclerosis: A Systematic Review
This review found that cognitive deficits significantly affect long-term disability and socio-professional reintegration in multiple sclerosis and other neurological disorders. It noted a lack of standardized approaches in cognitive neurorehabilitation and highlighted the need for precision-driven methodologies combining digital tools and clinical practices.
- Tags
- #Rehabilitation
- Most relevant to
- —
Why it matters
Understanding the impact of cognitive deficits on rehabilitation can inform improved strategies to enhance patient outcomes. However, the current variability in rehabilitation protocols hinders consistent effectiveness.
What this does not prove
The review identifies methodological issues like protocol heterogeneity, insufficient use of active control groups, short follow-up periods, and a disconnect between cognitive improvement and actual participation benefits.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- All
- Publication date
- 2026-10-04
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Rehabilitation, Other
Original sources
- Primary evidencePrecision cognitive neurorehabilitation: dose, adaptivity, digital therapeutics and implementation. ↗DOI: 10.1080/14737175.2026.2723909
Supporting passages (8)
study designClinical trials, systematic reviews, meta-analyses, and observational and proof-of-concept studies were prioritized.
subjectsThis brief narrative review examines restorative and compensatory cognitive neurorehabilitation for deficits of attention, executive functions, language and disorders of consciousness in people after stroke and traumatic brain injury (TBI), older adults, and those with neurological and neurodegenerative conditions, including multiple sclerosis, Alzheimer's and Parkinson's disease.
research categoriesEmphasis is placed on dose, frequency, adaptivity, personalization, and digital and technology-assisted interventions.
relevant ms typesmultiple sclerosis
publication date2026-10-04
interventionLarge-scale pragmatic trials, meaningful endpoints, and implementation strategies across the continuum of care will be essential to transform cognitive neurorehabilitation into a component of neurological practice.
findingsINTRODUCTION: Cognitive deficits are determinants of long-term disability and socio-professional reintegration across neurological disorders, including stroke, traumatic brain injury, multiple sclerosis, and neurodegenerative diseases.
limitationsMethodological challenges include heterogeneity of protocols, limited use of active control conditions, insufficient long-term follow-up, and the gap between cognitive test improvements and meaningful effects on participation.
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