VDR Genotype Analysis in Multiple Sclerosis Patients and Controls
A study on vitamin D receptor (VDR) genotypes compared 200 MS patients with 265 healthy controls. The analysis found no significant single variant associations with MS. However, a specific interaction between two gene variants was noted, and certain genotypes showed associations with motor symptoms and the absence of spinal cord lesions.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
This research contributes to understanding how genetic factors could relate to clinical features of MS; however, the lack of direct causal links means findings must be cautiously interpreted.
What this does not prove
The study did not find that investigated VDR variants independently affect MS susceptibility; it explored associations, not causation, between combinations of genotypes and clinical symptoms.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-05
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceVitamin D receptor gene variants and their association with clinical phenotypes of multiple sclerosis. ↗DOI: 10.1016/j.msard.2026.107962
Supporting passages (5)
comparatorGenotypic analysis for the SNVs was performed using genomic DNA extracted from samples of 200 MS patients and 265 neurologically healthy controls.
primary endpointThe study aimed to examine potential correlation between FokI (rs2228570), TaqI (rs731236), and BsmI (rs1544410) SNVs in VDR, and MS susceptibility, as well as clinical characteristics in a Southeastern European Caucasian case-control population.
findingsStatistical analysis indicated no significant associations between individual SNVs and MS susceptibility in univariate analyses.
limitationsWhile the investigated VDR variants do not appear to independently influence MS susceptibility, specific genotype combinations and alleles may contribute to the clinical expression of the disease.
publication datePublication date: 2026-10-05
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