Inductive Therapeutic Exercise in Adults with MS

In a pilot study, 30 adults with multiple sclerosis underwent 8 weeks of Inductive Therapeutic Exercise (ETI) or a sham procedure, each lasting 40 minutes per session. Measurements of muscle tone using a pendulum test were conducted at baseline, post-intervention, and one month later. The study aims to assess improved neuromuscular responses through ETI compared to sham.

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This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Why it matters

This research may enhance understanding of the impact of specific exercise techniques on muscle tone and postural control in MS patients. Findings could inform future interventions.

What this does not prove

No results have been reported yet. The small, nonrandomized sample size may limit generalizability. A nonrandom sequential procedure for group assignment may introduce bias, and results are preliminary due to the study's pilot nature.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Interventional
Participants / samples: 30 · basis not reported
Randomised: No
Controlled: Yes
Primary endpoint met: Not reported
Relevant MS type: Not reported
Publication date: Not reported
Evidence reviewed: Trial registry record
Regulatory approval: No
Research areas: Other

Original sources

Trial registrationInductive Therapeutic Exercise in Multiple Sclerosis ↗

Supporting passages (15)

study phase"interventionModelDescription": "This pilot study uses a nonrandomized, parallel-group design comparing Inductive Therapeutic Exercise (ETI, from the Spanish \"Ejercicio Terapéutico Inductivo\") with Sham Inductive Therapeutic Exercise (sham-ETI), a simulated intervention.

study designThe clinical intervention study is the focus of this trial registration.

subjectsParticipants will receive either Inductive Therapeutic Exercise (ETI, from the Spanish \"Ejercicio Terapéutico Inductivo\") or Sham Inductive Therapeutic Exercise (sham-ETI), a simulated intervention, with one individual session of approximately 40 minutes per week for 8 weeks.\n\nETI combines specific active movements and breathing patterns intended to elicit involuntary neuromuscular responses in other body regions.

speciesMeasurements obtained with the mobile tool will be compared with laboratory reference systems, and preliminary reference values will be established.\n\nThe second stage, which is the focus of this clinical trial registration, is a pilot controlled study involving approximately 30 adults with multiple sclerosis and altered muscle tone and standing postural control.

sample sizeMeasurements obtained with the mobile tool will be compared with laboratory reference systems, and preliminary reference values will be established.\n\nThe second stage, which is the focus of this clinical trial registration, is a pilot controlled study involving approximately 30 adults with multiple sclerosis and altered muscle tone and standing postural control.

randomizedGroup assignment will use a sequential balancing procedure that considers relevant baseline characteristics.

controlledMeasurements obtained with the mobile tool will be compared with laboratory reference systems, and preliminary reference values will be established.\n\nThe second stage, which is the focus of this clinical trial registration, is a pilot controlled study involving approximately 30 adults with multiple sclerosis and altered muscle tone and standing postural control.

regulatory approvalThe preceding observational tool-validation study is a separate preparatory component of ETOTUR and is not an intervention arm.",

research categoriesETOTUR will investigate whether a mobile tool can capture these features consistently and with sufficient agreement with laboratory reference systems to support its intended research use.\n\nThe therapeutic component investigates ETI as an approach combining specific active movements, positioning, and breathing patterns to elicit neuromuscular responses beyond the body region performing the voluntary movement.

intervention"description": "Participants will receive one individual session of Sham Inductive Therapeutic Exercise (sham-ETI), a simulated intervention, per week for 8 weeks, with each session lasting approximately 40 minutes.

comparator"description": "Participants will receive one individual session of Sham Inductive Therapeutic Exercise (sham-ETI), a simulated intervention, per week for 8 weeks, with each session lasting approximately 40 minutes.

primary endpoint"description": "Change from baseline in first swing excursion during the lower-limb pendulum test, assessed using the mobile measurement tool developed and validated in the preparatory study.

follow up"timeFrame": "From the first intervention session through the follow-up assessment approximately one month after completion of the 8-week intervention (approximately week 12)."

findingsThe main outcomes are lower-limb muscle tone assessed using the pendulum test, standing postural control measured with a pressure platform, and health-related quality of life assessed with the Multiple Sclerosis Quality of Life-54 questionnaire (MSQoL-54).

limitationsThese findings will help determine whether the intervention and assessment procedures are suitable for a larger study and which aspects require refinement.\n\nGiven the pilot sample, nonrandom allocation, and short follow-up period, the clinical findings will be interpreted as preliminary.

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