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Filters apply to reviewed research. Unknown dates and unassessed posts are excluded when a corresponding filter is active.

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AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyObservationalPeer review unconfirmed

Frailty and Mental Health in People with MS

In a study of 204 individuals with multiple sclerosis (MS), 50.5% were found to be frail. Frail participants were older and reported higher levels of anxiety and depression. They also had lower quality of life scores. Logistic regression suggested that higher anxiety and depression scores were associated with increased odds of frailty.

What this does not proveThe study established associations but did not confirm causality between frailty and mental health measures.
#Other
View abstract on PubMedPMID 42770074AI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyNot reportedTrial registry

Breastfeeding Individuals with RMS and BRIUMVI™

The study aims to determine how BRIUMVI™, a treatment for relapsing multiple sclerosis (RMS), is present in breast milk among breastfeeding participants. The key endpoint is to assess the concentration of BRIUMVI™ over time in breast milk.

What this does not proveNo results are available, and the plan for enrollment and study endpoints have not provided findings.
#Other
View abstract on PubMedAI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyPhase 1Trial registry

Human Trial of Nivolumab for Autoimmune Disorders including MS

This Phase Ib trial explores the safety and adverse effects of nivolumab in patients with various autoimmune disorders, including multiple sclerosis. The study design is interventional, involving about 300 estimated participants. It aims to evaluate the side effects and efficacy of nivolumab alone and with other treatments.

What this does not proveThere are no posted results for this trial, and the planned enrolment and endpoints are not indicative of findings.
#Other
View abstract on PubMedAI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyNot reportedTrial registry

Effect of the Lexical Association Technique on Self-Esteem in MS Patients

The study is currently recruiting 160 participants with relapsing-remitting and secondary progressive multiple sclerosis to evaluate the effectiveness of the Lexical Association Technique (LAT) on self-esteem. Participants will be randomized into an experimental group using LAT and a control group performing similar tasks without direct self-reference. Self-esteem will be measured via the Rosenberg Self-Esteem Scale at multiple time points after the intervention.

What this does not proveAs the study is still in the recruitment phase, no results regarding the effectiveness of LAT have been published or are available for evaluation, and thus, it does not demonstrate any definitive findings yet.
#Other
View abstract on PubMedAI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studySystematic reviewPeer-reviewed

Systematic Review of Mesenchymal Stem Cell (MSC) Therapy in Humans with Multiple Sclerosis

This systematic review analyzed 16 distinct clinical trials on MSC therapy for multiple sclerosis (MS). It found that MSC therapy is safe but showed mixed results in benefits, with some approaches indicating neuroprotection and no serious adverse events. However, a large trial did not show improvements in disability scales, and significant methodological differences and short follow-up periods across studies limit the conclusions.

What this does not proveDefinitive conclusions are constrained by significant methodological heterogeneity and short follow-up periods across trials. Findings on immunological markers were primarily from studies at high risk of bias.
#Other
View abstract on PubMedPMID 42764316AI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyPhase 2Peer review unconfirmed

Lacosamide Effects on Pain Management in Human MS Patients

In a Phase 2 randomized trial, lacosamide reduced pain severity in MS patients significantly compared to placebo (P = 0.001), with 90% of participants on lacosamide reporting improvements. Additional benefits included reduced pain interference, total NPSI scores, and enhanced SF-36 scores, with no serious side effects reported.

What this does not proveThe study lacked details on sample size and specific methodological aspects, limiting the interpretation of these results.
#Other
View abstract on PubMedPMID 42832970AI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyPhase 3Trial registry

Ublituximab in Relapsing Multiple Sclerosis: Human Study

This Phase 3b study aimed to evaluate the efficacy of a modified regimen of ublituximab in people with relapsing multiple sclerosis (RMS) by measuring the percentage of participants with no change or reduction in T1 Gd-enhancing lesions after 48 weeks.

What this does not proveResults have not been posted, and planned endpoints do not provide conclusive findings.
#Other
View abstract on PubMedAI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studySystematic reviewPeer-reviewed

Measurement Properties of WHODAS 2.0 in Adults with MS

A systematic review analyzed 28 reports on the WHODAS 2.0 in adults with MS. Moderate-certainty evidence indicated it has reliability and construct validity. Associations with quality of life and clinical severity had low-certainty evidence, while evidence on fatigue, mood, cognition, participation, and employment was of low to very low certainty. Comparisons were challenging due to varying methods and overlapping cohorts.

What this does not proveMost studies were cross-sectional, leading to limitations in understanding longitudinal effects. There was a lack of standardization in metrics and scoring methods, and the findings suggested measurement use but not treatment efficacy.
#Other
View abstract on PubMedPMID 42783414AI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyObservationalPeer review unconfirmed

Mothers with Multiple Sclerosis and Peripartum Mental Illness: A Study of 549,010 Cases

In a study of 549,010 mothers, 20.4% of those with multiple sclerosis experienced any mental illness during their first peripartum period, with 11.6% affected in the second period. Additionally, one-quarter received care for mental illness during the second period. Mothers with multiple sclerosis had a notably higher prevalence of conditions like depression and anxiety than those without similar chronic diseases.

What this does not proveThe study's observational design prevents it from establishing any causal relationships between multiple sclerosis and peripartum mental illness.
#Other
View abstract on PubMedPMID 42813743AI summary of a published abstract. Not medical advice.
AI CuratorAI-generated
Research summary ·
AI summary · not yet reviewedHuman studyObservationalPeer review unconfirmed

Gait Coordination in People with MS

A study involving 65 people with multiple sclerosis (MS) and 43 matched unaffected individuals assessed gait coordination using a six-minute walk test. It found that patients with MS had significantly poorer coordination compared to the unaffected group, with particular deficits noted in the knee-ankle joint.

What this does not proveThe study does not prove that observed coordination deficits directly relate to therapeutic effectiveness or improvement in clinical outcomes. It mainly contributes to knowledge on gait metrics rather than treatment implications.
#Other
View abstract on PubMedPMID 42763819AI summary of a published abstract. Not medical advice.