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Impact of Familial Multiple Sclerosis on Disease Progression in Human Subjects
In a study of 3,094 individuals with multiple sclerosis (MS), no significant links were found between having a family history of MS and long-term disability progression, cognitive decline, or MRI activity. Hazard ratios for disability worsening among those with first and second-/third-degree relatives were close to 1.0, indicating minimal difference compared to those without a known family history.
What this does not proveThis study does not prove that familial MS influences long-term outcomes, and the reasons behind these observations remain unclear.